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These acupoints belong to either the same meridian or related meridians.

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Bromides may owe their sedative effect to a family connection.

Also, SSRIs have very different molecular structures. Zoloft (Sertraline hydrochloride) was the second SSRI to come to market in the United States, and it was approved by the FDA in December 30, 1991. Paxil (Paroxetine hydrochloride) was the third SSRI to come to market in the United States and was approved by the FDA in December 29, 1992. Chemical structure of Paroxetine differs from other SSRIs by having a piperidine ring.

The first drug in the SSRI class was Prozac (Fluoxetine), which hit the United States market in 1987. Luvox (Fluvoxamine maleate) was the next SSRI FDA approved in December 05, 1994.

This leads to differences among the SSRIs in their half-lives, clinical activity, side effects, and drug interactions.

There are differences between SSRIs that could be clinically significant.